I imagine CircuitPython becoming a very easy way to create serious IoT sensor nodes. CP, with Adafruit sensor breakouts, could be used to code the sensor logic.
What I would like to see in #CircuitPython2022 is the ability to work over an RTOS, like FreeRTOS or Zephyr, so that a proper communications stack could be implemented in the background, transparent to the user. This has been successful in ESP series but I'd like to see STM32 or Nordic chips support the same.
For a specific example, think of LoRaWAN. Most aspects of LoRaWAN can be implemented with open source, but the LoRaWAN stacks for microcontrollers are not compliant with LoRa Alliance and deliver a very poor user experience compared to what is possible with LoRaWAN. An underlying RTOS will support implementing a proper, certifiable, stack for LoRaWAN (from FOSS) that will enable the full LoRaWAN functionality.